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Pox
Sorcery
Each player loses a third of their life, then discards a third of the cards in their hand, then sacrifices a third of the creatures they control, then sacrifices a third of the lands they control. Round up each time.
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Duel Commander
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Did you know?
Largepox is a reference to Pox and Smallpox and list pretty much all the negative effects of the game.